Team 1 – Genomics and Pathophysiology of Myocardial Diseases

Team headed by P. Charron:

Team 1 focuses its research program on 4 research axes :

  • To identify key-players (rare and frequent genetic variants, signaling pathways) in cardiomyopathies and channelopathies through genomics and omics approaches.
  • To understand function, interactions and pathophysiology of key-players in these diseases through human cardiomyocytes (derived from iPS patients) and murine models.
  • To translate the new knowledge into clinical practice, especially through genetic testing and high throughput resequencing, to develop personalized medicine.
  • To progress towards new therapeutics (pharmacologic, interventional, gene-based) in monogenic or complex forms of heart failure and arrhythmias.

This team is linked to the “école doctorale” 394 “Physiologie, Physiopathologie et Thérapeutique”.