Team 1 – Genomics and Pathophysiology of Cardiovascular Diseases

Team headed by D.A. Trégouët

Team 1 focuses its research program on – identification of new genes and genetic variants associated to the susceptibility to rare or frequent cardiovascular diseases, – characterization of their functional roles at the molecular and cellular levels, – finding new pathophysiological mechanisms, in the ultimate goal of a better therapeutic management of patients. This research is built on the use of genetic and transcriptomic techniques (“Micro-array” and “Next-Generation-Sequencing”) and on functional studies of identified genes/variants. The main studied diseases are cardiomyopathies, arrhythmias, coronary artery disease and venous thrombosis.

This team is linked to both “écoles doctorales” 515 “Complexité du Vivant” and 393 “Santé Publique: Epidémiologie & Sciences de l’Information Biomédicale”.

 

Team 2 – Biology and Pharmacology of Cardiovascular Remodeling

Team headed by F. Soubrier

Team 2 focuses its research on understanding the molecular and cellular mechanisms involved in cardiac and vascular remodeling under pathological conditions. This team combines gene transfer using viral vectors, transgenic animal models, important human bioressources and strong interactions with physicians and partners from the industry to develop a translational research.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.

 

Team 3 – Pathophysiology of Cellular Excitability

Team 3 is headed by S. Hatem.

Team 3 focuses its research program on the identification of molecular mechanisms underlying cardiac ion channel trafficking and their role in the pathophysiology of cardiac arrhythmias with a strong emphasis on atrial fibrillation. Using cardiac myocyte electrophysiology, molecular imaging of living cells and experimental models of cardiac diseases, team 3 studies the mechanisms underlying cardiac remodeling, atrial excitability modifications and the substrate of atrial fibrillation.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.

 

Team 4 – Integrative Biology of Atherosclerosis

Team headed by P. Lesnik

Team 4 focuses its research on the lipido-inflammatory dimension of atherosclerotic vascular disease, the structure, metabolism and function of lipoproteins, the molecular genetics of cholesterol transport and homeostasis, and the systemic biomarkers of cardiometabolic diseases. This research has three main objectives: (i) to determine how lipids and immune cells crosstalk to influence atherogenesis, (ii) to determine the clinical relevance of novel mechanisms, genes, and biomarkers by studies of human diseases, and (iii) to evaluate and develop novel therapeutic approaches for inflammatory and metabolic disorders and atherosclerosis.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.

 

Team 6 – NutriOmics: Nutrition and Obesity; Systemic Approaches

Team headed by K. Clément

Team 6 focuses its research on pathophysiological mechanisms underlying the development of human obesity and its comorbidities via translational approaches and systems biology. Several aims are developed: i) to explore the perturbation in organ cross-talks and particularly the role of adipose tissue, ii) to find ways to better stratify the disease and improve cardiometabolic health by innovative therapies.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.