Team 4 – Integrative Biology of Atherosclerosis

Team headed by P. Lesnik

Team 4 focuses its research on the lipido-inflammatory dimension of atherosclerotic vascular disease, the structure, metabolism and function of lipoproteins, the molecular genetics of cholesterol transport and homeostasis, and the systemic biomarkers of cardiometabolic diseases. This research has three main objectives: (i) to determine how lipids and immune cells crosstalk to influence atherogenesis, (ii) to determine the clinical relevance of novel mechanisms, genes, and biomarkers by studies of human diseases, and (iii) to evaluate and develop novel therapeutic approaches for inflammatory and metabolic disorders and atherosclerosis.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.

 

Team 6 – NutriOmics: Nutrition and Obesity; Systemic Approaches

Team headed by K. Clément

Team 6 focuses its research on pathophysiological mechanisms underlying the development of human obesity and its comorbidities via translational approaches and systems biology. Several aims are developed: i) to explore the perturbation in organ cross-talks and particularly the role of adipose tissue, ii) to find ways to better stratify the disease and improve cardiometabolic health by innovative therapies.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.