Team 4 – Integrative Biology of Atherosclerosis

Team headed by P. Lesnik

Team 4 focuses its research on the lipido-inflammatory dimension of atherosclerotic vascular disease, the structure, metabolism and function of lipoproteins, the molecular genetics of cholesterol transport and homeostasis, and the systemic biomarkers of cardiometabolic diseases. This research has three main objectives: (i) to determine how lipids and immune cells crosstalk to influence atherogenesis, (ii) to determine the clinical relevance of novel mechanisms, genes, and biomarkers by studies of human diseases, and (iii) to evaluate and develop novel therapeutic approaches for inflammatory and metabolic disorders and atherosclerosis.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.