Team 1 – Genomics and Pathophysiology of Cardiovascular Diseases

Team headed by D.A. Trégouët

Team 1 focuses its research program on – identification of new genes and genetic variants associated to the susceptibility to rare or frequent cardiovascular diseases, – characterization of their functional roles at the molecular and cellular levels, – finding new pathophysiological mechanisms, in the ultimate goal of a better therapeutic management of patients. This research is built on the use of genetic and transcriptomic techniques (“Micro-array” and “Next-Generation-Sequencing”) and on functional studies of identified genes/variants. The main studied diseases are cardiomyopathies, arrhythmias, coronary artery disease and venous thrombosis.

This team is linked to both “écoles doctorales” 515 “Complexité du Vivant” and 393 “Santé Publique: Epidémiologie & Sciences de l’Information Biomédicale”.

 

Team 3 – Pathophysiology of Cellular Excitability

Team 3 is headed by S. Hatem.

Team 3 focuses its research program on the identification of molecular mechanisms underlying cardiac ion channel trafficking and their role in the pathophysiology of cardiac arrhythmias with a strong emphasis on atrial fibrillation. Using cardiac myocyte electrophysiology, molecular imaging of living cells and experimental models of cardiac diseases, team 3 studies the mechanisms underlying cardiac remodeling, atrial excitability modifications and the substrate of atrial fibrillation.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.