Team 2 – Biology and Pharmacology of Cardiovascular Remodeling

Team headed by F. Soubrier

Team 2 focuses its research on understanding the molecular and cellular mechanisms involved in cardiac and vascular remodeling under pathological conditions. This team combines gene transfer using viral vectors, transgenic animal models, important human bioressources and strong interactions with physicians and partners from the industry to develop a translational research.

This team is attached to the “école doctorale” 394 “Physiologie et Physiopathologie”.

 

Principal investigators’ groups:

  • In Team 2, Florent Soubrier and Sophie Nadaud lead research works on the molecular and cellular actors involved in vascular remodeling during pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD). PAH is a rare disease characterized by a thickening of the vascular walls and occlusion of the vessels leading to right cardiac failure. PVOD mainly involves small pulmonary veins with a progressive occlusion due to fibrosis and capillary proliferation. The group has identified new pulmonary vascular progenitor cells which proliferate and differentiate into new vascular smooth muscle cells during PAH. They also study the role of new proteins which regulate the function of vascular endothelial and smooth muscle cells. Their work combines genetic studies to identify new genes, such as GCN2 responsible for the hereditary PVOD, and studies on cultured cells or animal models with gene deletion, molecular biology, biochemistry, tissue and cell imaging and flow cytometry.